Browse Titles - 37 results
Can Autism Be Explained by Biological Causes and Hence Be Treated Medically?
(Latest Thinking, 2017), 9 mins
Autism spectrum disorders are largely of genetic origin, and 5-10% of cases are currently known to be caused by a single gene mutation. Understanding the consequences of these mutations in detail can open the way for medical treatment. The study presented in this video focused on how a frequent mutation seen in pa...
Open Access
(Latest Thinking, 2017), 9 mins
Description
Autism spectrum disorders are largely of genetic origin, and 5-10% of cases are currently known to be caused by a single gene mutation. Understanding the consequences of these mutations in detail can open the way for medical treatment. The study presented in this video focused on how a frequent mutation seen in patients with autism spectrum disorders causes the brain dysfunction that leads to the behavioral symptoms. Based on mice with the same g...
Autism spectrum disorders are largely of genetic origin, and 5-10% of cases are currently known to be caused by a single gene mutation. Understanding the consequences of these mutations in detail can open the way for medical treatment. The study presented in this video focused on how a frequent mutation seen in patients with autism spectrum disorders causes the brain dysfunction that leads to the behavioral symptoms. Based on mice with the same genetic lesion that is known to cause autism spectrum disorder in human patients, mutant brains and nerve cells and the behavior of mutant mice were examined. The mice showed clear signs of autism related behavioral defects, and further analyses provided insights into the changes in brain function that are caused by the gene mutation, as NILS BROSE explains in this video. The corresponding data show that synapses of nerve cells that use the neurotransmitter GABA are particularly affected by the mutation. If these results can be confirmed to reflect the situation in the human body, there would be a chance to interfere with medication targeting GABAergic synapses.
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Field of Study
Health Policy
Content Type
Instructional material
Contributor
Nils Brose, fl. 1995
Date Published / Released
2017
Publisher
Latest Thinking
Speaker / Narrator
Nils Brose, fl. 1995
Person Discussed
Nils Brose, fl. 1995
Topic / Theme
Genetic and hereditary diseases, Autism spectrum disorder, Biology
Copyright Message
Copyright © 2017 Latest Thinking
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Can Biosignatures Be Used to Develop a Reliable, Fast and Low-Cost Test for Tuberculosis?
(Hamburg, Hamburg State: Latest Thinking, 2017), 8 mins
Tuberculosis is still a major health issue and the number one killer of all contagious diseases. But while more than 2 billion people are infected with the tuberculosis agent, only 10% develop an active disease. Current diagnostic tests cannot distinguish between infected people and people with active tuberculosis...
Open Access
(Hamburg, Hamburg State: Latest Thinking, 2017), 8 mins
Description
Tuberculosis is still a major health issue and the number one killer of all contagious diseases. But while more than 2 billion people are infected with the tuberculosis agent, only 10% develop an active disease. Current diagnostic tests cannot distinguish between infected people and people with active tuberculosis. In this video, STEFAN H. E. KAUFMANN explains that they found a characteristic gene expression profile of people infected with tuberc...
Tuberculosis is still a major health issue and the number one killer of all contagious diseases. But while more than 2 billion people are infected with the tuberculosis agent, only 10% develop an active disease. Current diagnostic tests cannot distinguish between infected people and people with active tuberculosis. In this video, STEFAN H. E. KAUFMANN explains that they found a characteristic gene expression profile of people infected with tuberculosis. Relying on only four markers they developed a highly sensitive method that is not only able to identify people with active tuberculosis but is also suitable for point of care application in countries with low resources.
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Field of Study
Health Policy
Content Type
Instructional material
Date Published / Released
2017
Publisher
Latest Thinking
Speaker / Narrator
Stefan Hugo Ernst Kaufmann, 1948-
Person Discussed
Stefan Hugo Ernst Kaufmann, 1948-
Topic / Theme
Tuberculosis
Copyright Message
Copyright © 2017 Latest Thinking
×
Collaborative care planning to improve usage of hearing aids
produced by University of Surrey (Surrey, England: University of Surrey, 2015), 4 mins
This thesis examines the reasons why a significant number of patients do not wear hearing aids, as well as the link to collaborative care planning to improve usage of hearing aids that leads to improved quality of life.
Open Access
produced by University of Surrey (Surrey, England: University of Surrey, 2015), 4 mins
Description
This thesis examines the reasons why a significant number of patients do not wear hearing aids, as well as the link to collaborative care planning to improve usage of hearing aids that leads to improved quality of life.
Field of Study
Health Policy
Content Type
Lecture/presentation
Contributor
University of Surrey
Date Published / Released
2015
Publisher
University of Surrey
Topic / Theme
Hearing aids, Scientific research
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Do Financial Incentives Help Obese People to Achieve and to Maintain a Target Weight?
(Latest Thinking, 2017), 9 mins
By means of a field experiment, the research presented in this video tested the effects of financial incentives on the dieting behavior of obese people. As CHRISTOPH M. SCHMIDT explains, patients leaving rehabilitation clinics have been selected for the study and were given different treatments to help them achiev...
Open Access
(Latest Thinking, 2017), 9 mins
Description
By means of a field experiment, the research presented in this video tested the effects of financial incentives on the dieting behavior of obese people. As CHRISTOPH M. SCHMIDT explains, patients leaving rehabilitation clinics have been selected for the study and were given different treatments to help them achieve their target weight. It shows that those patients who received a financial incentive were more successful in sustaining healthy behav...
By means of a field experiment, the research presented in this video tested the effects of financial incentives on the dieting behavior of obese people. As CHRISTOPH M. SCHMIDT explains, patients leaving rehabilitation clinics have been selected for the study and were given different treatments to help them achieve their target weight. It shows that those patients who received a financial incentive were more successful in sustaining healthy behavior in the short term, with the effect weakening over time. These insights contribute to the question of the role financial incentives can play in encouraging healthy behavior.
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Field of Study
Health Policy
Content Type
Instructional material
Contributor
Christoph Matthias Schmidt, 1962-
Date Published / Released
2017
Publisher
Latest Thinking
Speaker / Narrator
Christoph Matthias Schmidt, 1962-
Person Discussed
Christoph Matthias Schmidt, 1962-
Topic / Theme
Rehabilitation, Personal finances, Obesity
Copyright Message
Copyright © 2017 Latest Thinking
×
The First Wave, A Panel Conversation: Lessons from the Pandemic for a Brighter Future
directed by Matthew Heineman, fl. 2003; produced by Leslie Norville, Jenna Millman and Matthew Heineman, fl. 2003 (Ann Arbor, MI: ProQuest, 2022), 1 hour 5 mins
In this conversation, director Matthew Heineman, Academy Award®-nominated and Emmy® Award-winning filmmaker, and Dr. Nathalie Dougé, the frontline doctor in The First Wave, share their inspiring first-hand experiences. Moderated by J. Corey Feist, JD, MBA, President and Co-Founder of the Lorna Breen Heroes' Fou...
Open Access
directed by Matthew Heineman, fl. 2003; produced by Leslie Norville, Jenna Millman and Matthew Heineman, fl. 2003 (Ann Arbor, MI: ProQuest, 2022), 1 hour 5 mins
Description
In this conversation, director Matthew Heineman, Academy Award®-nominated and Emmy® Award-winning filmmaker, and Dr. Nathalie Dougé, the frontline doctor in The First Wave, share their inspiring first-hand experiences. Moderated by J. Corey Feist, JD, MBA, President and Co-Founder of the Lorna Breen Heroes' Foundation, topics discussed include how the film will serve as a primary source document of this extraordinary moment in time, how health...
In this conversation, director Matthew Heineman, Academy Award®-nominated and Emmy® Award-winning filmmaker, and Dr. Nathalie Dougé, the frontline doctor in The First Wave, share their inspiring first-hand experiences. Moderated by J. Corey Feist, JD, MBA, President and Co-Founder of the Lorna Breen Heroes' Foundation, topics discussed include how the film will serve as a primary source document of this extraordinary moment in time, how healthcare professionals managed the mental and social impacts of COVID-19, and the positive impacts the pandemic has brought to the profession.
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Field of Study
Media Studies
Content Type
Panel discussion
Contributor
J. Corey Feist, Dr. Nathalie Dougé, Matthew Heineman, fl. 2003, Leslie Norville, Jenna Millman
Author / Creator
Matthew Heineman, fl. 2003
Date Published / Released
2022
Publisher
ProQuest
Topic / Theme
Crisis management, Pandemics
Copyright Message
Copyright © 2022 ProQuest a part of Clarivate
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How Can Biomaterial Scaffolds Help to Repair Damaged Spinal Cords by Guiding Nerves to Grow Across the Injury?
(Germany: Latest Thinking, 2017), 12 mins
In the 1980s researchers showed that damaged nerves in the spinal cord have the ability to regrow. Chemical engineers contribute to the field of spinal cord repair by developing biomaterial scaffolds that support cell and nerve growth inside the body after an injury. In the research project explained by LAURA DE L...
Open Access
(Germany: Latest Thinking, 2017), 12 mins
Description
In the 1980s researchers showed that damaged nerves in the spinal cord have the ability to regrow. Chemical engineers contribute to the field of spinal cord repair by developing biomaterial scaffolds that support cell and nerve growth inside the body after an injury. In the research project explained by LAURA DE LAPORTE in this video, such scaffolds were developed and tested: The special architecture of the developed structures uses oriented chan...
In the 1980s researchers showed that damaged nerves in the spinal cord have the ability to regrow. Chemical engineers contribute to the field of spinal cord repair by developing biomaterial scaffolds that support cell and nerve growth inside the body after an injury. In the research project explained by LAURA DE LAPORTE in this video, such scaffolds were developed and tested: The special architecture of the developed structures uses oriented channels to guide the nerves to grow across the site of injury. Moreover, delivering DNA via the scaffolds resulted in growth of specific proteins that further stimulated the nerve cells to grow. The research project shows that the developed scaffolds can be used twofold: As an architecture, a physical help for the nerves to grow, but also to deliver significant crucial growth factors that are necessary to further stimulate spinal cord repair.
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Field of Study
Health Policy
Content Type
Instructional material
Date Published / Released
2017
Publisher
Latest Thinking
Speaker / Narrator
Laura De Laporte, fl. 2004
Person Discussed
Laura De Laporte, fl. 2004
Topic / Theme
Medical tools, Medical treatments and procedures, Scientific research
Copyright Message
Copyright © 2017 Latest Thinking
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How Can Chronic Lymphocytic Leukemia Be Treated Effectively in a Variety of Patients?
(Germany: Latest Thinking, 2017), 12 mins
One the most common types of leukemia is chronic lymphocytic leukemia. To find the right treatment for an individual patient with that disease is a challenging task and many patients develop a resistance against the existing drugs. The purpose of the research presented by BRIGITTE VOIT in this video is to find new...
Open Access
(Germany: Latest Thinking, 2017), 12 mins
Description
One the most common types of leukemia is chronic lymphocytic leukemia. To find the right treatment for an individual patient with that disease is a challenging task and many patients develop a resistance against the existing drugs. The purpose of the research presented by BRIGITTE VOIT in this video is to find new drugs that reduce cancer cells while not destroying other cells in the body. The researchers created two versions of organic molecules...
One the most common types of leukemia is chronic lymphocytic leukemia. To find the right treatment for an individual patient with that disease is a challenging task and many patients develop a resistance against the existing drugs. The purpose of the research presented by BRIGITTE VOIT in this video is to find new drugs that reduce cancer cells while not destroying other cells in the body. The researchers created two versions of organic molecules called dendrimers, differentiated by type of shell, and compared their effect to that of the commercial drug Fludarabine. The findings are highly relevant for treatment of leukemia: Both types of dendrimers destroy leukemia cells but one of them is more active against cancer cells and at the same time less harmful for healthy cells than Fludarabine. Moreover, the dendrimers have an effect on leukemia cells that are resistant to commonly used treatments.
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Field of Study
Health Policy
Content Type
Instructional material
Date Published / Released
2017
Publisher
Latest Thinking
Speaker / Narrator
Brigitte Voit, 1963-
Person Discussed
Brigitte Voit, 1963-
Topic / Theme
Scientific research, Drugs and pharmaceuticals, Cancer, Cancer therapies
Copyright Message
Copyright © 2017 Latest Thinking
×
How Can Functional Magnetic Resonance Imaging Help Detect, Visualize, and Treat Strokes?
(Germany: Latest Thinking, 2017), 11 mins
Stroke is one of the most frequent neurological disorders, befalling over 250.000 persons each year in Germany alone. The research underlying this video explores the role of non-invasive methods for stroke diagnosis and therapy. The use of functional Magnetic Resonance Imaging (fMRI), which produces image-signals...
Open Access
(Germany: Latest Thinking, 2017), 11 mins
Description
Stroke is one of the most frequent neurological disorders, befalling over 250.000 persons each year in Germany alone. The research underlying this video explores the role of non-invasive methods for stroke diagnosis and therapy. The use of functional Magnetic Resonance Imaging (fMRI), which produces image-signals on the basis of the oxygen-concentration in the blood, allows for the detection of increased or decreased activity in the brain. ARNO V...
Stroke is one of the most frequent neurological disorders, befalling over 250.000 persons each year in Germany alone. The research underlying this video explores the role of non-invasive methods for stroke diagnosis and therapy. The use of functional Magnetic Resonance Imaging (fMRI), which produces image-signals on the basis of the oxygen-concentration in the blood, allows for the detection of increased or decreased activity in the brain. ARNO VILLRINGER explains how this method helps detect affected networks of the brain in the acute phase and enables a tracking progress in the chronic phase of a stroke: The networks of disturbed blood flow in the brain correspond to changes in the neurological functions of the patient. By identifying and visualizing the affected areas non-invasively a continuous monitoring of the patient and a targeted application of treatments, e.g. magnetic stimulation or drugs, is possible and is already tested in clinical studies.
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Field of Study
Medical Imaging
Content Type
Instructional material
Date Published / Released
2017
Publisher
Latest Thinking
Speaker / Narrator
Arno Villringer, 1958-
Person Discussed
Arno Villringer, 1958-
Topic / Theme
Strokes, Medical treatments and procedures, Brain
Copyright Message
Copyright © 2017 Latest Thinking
×
How Can Magnetic Resonance Imaging Be Improved for Early Disease Detection?
(Latest Thinking, 2017), 7 mins
The technique of Magnetic Resonance Imaging, or short MRI, is a useful and widely used tool in clinical diagnostics. However, the current MRI techniques are not sensitive enough to detect low concentrations of drugs or disease related molecules. LEIF SCHRÖDER explains that MRI is typically based on the detection...
Open Access
(Latest Thinking, 2017), 7 mins
Description
The technique of Magnetic Resonance Imaging, or short MRI, is a useful and widely used tool in clinical diagnostics. However, the current MRI techniques are not sensitive enough to detect low concentrations of drugs or disease related molecules. LEIF SCHRÖDER explains that MRI is typically based on the detection of water molecules. However, the high water concentration that is always present in the body creates a strong background signal obstruc...
The technique of Magnetic Resonance Imaging, or short MRI, is a useful and widely used tool in clinical diagnostics. However, the current MRI techniques are not sensitive enough to detect low concentrations of drugs or disease related molecules. LEIF SCHRÖDER explains that MRI is typically based on the detection of water molecules. However, the high water concentration that is always present in the body creates a strong background signal obstructing the signal of dilute molecules so only substances at higher concentrations can be found. In the new approach presented in this video, the researchers used the noble gas Xenon, manipulated its magnetic properties and paired it with a contrast agent which senses specific molecules related to cancer. With this technique, they managed to visualize also molecules in very low concentrations as it is the case for early onset cancer. This approach can help to spot diseases at a very early stage or support drug development.
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Field of Study
Health Policy
Content Type
Instructional material
Contributor
Leif Schröder, fl. 2009
Date Published / Released
2017
Publisher
Latest Thinking
Topic / Theme
Biology, Cancer
Copyright Message
Copyright © 2017 Latest Thinking
×
How Can the Toxic Effects of Chemical Compounds on Humans Be Predicted by Means of Crowdsourcing?
(Germany: Latest Thinking, 2017), 8 mins
As humans react differently to chemical substances one of the challenges for public health is to establish which compounds are harmful for whom. The research project presented in this video uses crowdsourcing as part of the DREAM challenges as a method to improve research on this topic by involving the scientific...
Open Access
(Germany: Latest Thinking, 2017), 8 mins
Description
As humans react differently to chemical substances one of the challenges for public health is to establish which compounds are harmful for whom. The research project presented in this video uses crowdsourcing as part of the DREAM challenges as a method to improve research on this topic by involving the scientific community. Data on different reactions to chemical compounds were shared with scientists all over the world. They analyzed the data wit...
As humans react differently to chemical substances one of the challenges for public health is to establish which compounds are harmful for whom. The research project presented in this video uses crowdsourcing as part of the DREAM challenges as a method to improve research on this topic by involving the scientific community. Data on different reactions to chemical compounds were shared with scientists all over the world. They analyzed the data with different methods and every participating group described their methods and findings in detail. JULIO SAEZ-RODRIGUEZ explains how the outcomes show that the combination of all suggestions allowed for a better prediction of reactions to chemicals. In general, the findings show that crowdsourcing has positive effects on science as it accelerates research, and that it is a powerful resource for computational biomedicine.
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Field of Study
Health Policy
Content Type
Instructional material
Date Published / Released
2017
Publisher
Latest Thinking
Speaker / Narrator
Julio Saez-Rodriguez, fl. 2010
Person Discussed
Julio Saez-Rodriguez, fl. 2010
Topic / Theme
Scientific method, Scientific research
Copyright Message
Copyright © 2017 Latest Thinking
×